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The microbiomegutbrain axis in Parkinson disease from basic research to the clinic

Furthermore, a fact that has attracted attention in recent years is that dietary L-carnitine appears to cause the acceleration of atherosclerosis, owing to its conversion in the body to trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) by enteric bacteria 19

Zhou Y, Huang J

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Notably, cachexia can be mediated by autophagy in lung cancer patients where BCL2 adenovirus E1B 19-kDa-interacting protein 3 (BNIP3) and Microtubule Associated Protein 1 Light Chain 3 Beta (LC3B) are the major players (Tardif et al., 2013)

As evidenced in db/db and ob/ob mouse models (Thaiss et al., 2018), sustained hyperglycemia activates intestinal epithelial glucose transporter 2 (GLUT2) and downregulates the expression of zonula occludens-1 (ZO-1), increasing intestinal permeability